Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 114237..115012 Replicon chromosome
Accession NZ_LR594689
Organism Variovorax sp. WDL1

Toxin (Protein)


Gene name yhaV Uniprot ID V6ADY6
Locus tag E5P1_RS00645 Protein ID WP_009518525.1
Coordinates 114237..114695 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID V6AEP7
Locus tag E5P1_RS00650 Protein ID WP_023098543.1
Coordinates 114695..115012 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5P1_RS00620 109578..110525 + 948 WP_009518520.1 TIGR03756 family integrating conjugative element protein -
E5P1_RS00625 110535..111929 + 1395 WP_102905818.1 integrating conjugative element protein -
E5P1_RS00630 111926..112285 + 360 WP_009518522.1 hypothetical protein -
E5P1_RS00635 112300..113817 + 1518 WP_009518523.1 conjugal transfer protein TraG N-terminal domain-containing protein -
E5P1_RS00640 113833..114210 - 378 WP_009518524.1 DUF3742 family protein -
E5P1_RS00645 114237..114695 - 459 WP_009518525.1 type II toxin-antitoxin system YhaV family toxin Toxin
E5P1_RS00650 114695..115012 - 318 WP_023098543.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
E5P1_RS00655 115312..117126 + 1815 WP_068681684.1 TraI domain-containing protein -
E5P1_RS00660 117226..117939 + 714 WP_068673446.1 UPF0149 family protein -
E5P1_RS00665 117970..119535 - 1566 WP_102905039.1 IS66 family transposase -
E5P1_RS00670 119630..119983 - 354 WP_068673444.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(8-144)

Antitoxin

PrlF antitoxin

(8-100)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17660.02 Da        Isoelectric Point: 10.1848

>T288585 WP_009518525.1 NZ_LR594689:c114695-114237 [Variovorax sp. WDL1]
MQRHGWTLLFHDCVIEQLQKLHAAARRAQENDPAGFESNANVKLFRALSQLMLDVVPGDPARDEYRQGNTLGPAHRHWRR
AKIGRRFRLFFRYDSKAKVIVYAWVNDEQTLRSSGSKSDPYVVFEKMLGRGNPPDDWHALIQASKQDWSKLE

Download         Length: 459 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11170.72 Da        Isoelectric Point: 4.7182

>AT288585 WP_023098543.1 NZ_LR594689:c115012-114695 [Variovorax sp. WDL1]
MPAIHEVATLTSKGQITLPKPIRQALGVDAGGKLAFDLRGSEVVVTRVDAEHEDPAIGAFLSLLARDIEAGRNVRGLPED
LARAMLEHAGHGVNLDEEIDGKVEL

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ADY6

Antitoxin

Source ID Structure
AlphaFold DB V6AEP7

References