Detailed information of TA system TA288560

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2765667..2766004
• Replicon: chromosome
• Accession: NZ_LR594051
• Organism: Enterococcus faecalis strain NCTC8732

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E2Z0W4
• Locus tag: FGL29_RS14380
• Protein ID: WP_002381035.1
• Coordinates: 2765667..2765810 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2765742..2766004 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGL29_RS14355	2761771..2762400	-	630	WP_002354763.1	lytic polysaccharide monooxygenase	-
FGL29_RS14365	2763093..2764709	+	1617	WP_002381036.1	phosphatase PAP2/LCP family protein	-
FGL29_RS14370	2765039..2765182	+	144	WP_002392818.1	putative holin-like toxin	-
FGL29_RS14375	2765301..2765441	+	141	WP_073340360.1	putative holin-like toxin	-
FGL29_RS14380	2765667..2765810	+	144	WP_002381035.1	putative holin-like toxin	Toxin
-	2765742..2766004	-	263	-	-	Antitoxin
FGL29_RS14385	2766005..2770696	-	4692	WP_010783624.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5202.20 Da
• Isoelectric Point: 10.0041

>T288560 WP_002381035.1 NZ_LR594051:2765667-2765810 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 263 bp

>AT288560 NZ_LR594051:c2766004-2765742 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A2Z6BWH2

Antitoxin