288558

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2765374..2765810 Replicon chromosome
Accession NZ_LR594051
Organism Enterococcus faecalis strain NCTC8732

Toxin (Protein)


Gene name txpA Uniprot ID E2Z0W4
Locus tag FGL29_RS14380 Protein ID WP_002381035.1
Coordinates 2765667..2765810 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2765374..2765572 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL29_RS14350 2760515..2761507 + 993 WP_002354765.1 biotin--[acetyl-CoA-carboxylase] ligase -
FGL29_RS14355 2761771..2762400 - 630 WP_002354763.1 lytic polysaccharide monooxygenase -
FGL29_RS14365 2763093..2764709 + 1617 WP_002381036.1 phosphatase PAP2/LCP family protein -
FGL29_RS14370 2765039..2765182 + 144 WP_002392818.1 putative holin-like toxin -
FGL29_RS14375 2765301..2765441 + 141 WP_073340360.1 putative holin-like toxin -
- 2765374..2765572 - 199 - - Antitoxin
FGL29_RS14380 2765667..2765810 + 144 WP_002381035.1 putative holin-like toxin Toxin
FGL29_RS14385 2766005..2770696 - 4692 WP_010783624.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5202.20 Da        Isoelectric Point: 10.0041

>T288558 WP_002381035.1 NZ_LR594051:2765667-2765810 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 199 bp

>AT288558 NZ_LR594051:c2765572-2765374 [Enterococcus faecalis]
TTTTTAGGTAATTGTGCTATAATGGTAATGAAAAGAGAGCTATGCTGTAACATACCTCTCTGATGTAGAGCCGTTTAAGA
CGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z6BWH2

Antitoxin

Download structure file

References