288547

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2680371..2680834 Replicon chromosome
Accession NZ_LR594051
Organism Enterococcus faecalis strain NCTC8732

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag FGL29_RS13955 Protein ID WP_002392696.1
Coordinates 2680371..2680514 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2680690..2680834 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL29_RS13940 2675617..2676330 - 714 WP_002381063.1 trehalose operon repressor -
FGL29_RS13945 2676592..2679336 + 2745 WP_002398920.1 glycoside hydrolase family 65 protein -
FGL29_RS13950 2679351..2680001 + 651 WP_002354875.1 beta-phosphoglucomutase -
FGL29_RS13955 2680371..2680514 - 144 WP_002392696.1 putative holin-like toxin Toxin
- 2680690..2680834 + 145 - - Antitoxin
FGL29_RS13960 2681331..2681863 + 533 Protein_2589 CPBP family intramembrane metalloprotease -
FGL29_RS13965 2681917..2682888 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
FGL29_RS13970 2683063..2683500 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
FGL29_RS13975 2683633..2684187 - 555 WP_002354869.1 septum formation protein Maf -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T288547 WP_002392696.1 NZ_LR594051:c2680514-2680371 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 145 bp

>AT288547 NZ_LR594051:2680690-2680834 [Enterococcus faecalis]
TTGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACCGAT
TTTGTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAACA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References