Detailed information of TA system TA288545

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2680251..2680514
• Replicon: chromosome
• Accession: NZ_LR594051
• Organism: Enterococcus faecalis strain NCTC8732

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: FGL29_RS13955
• Protein ID: WP_002392696.1
• Coordinates: 2680371..2680514 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2680251..2680438 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGL29_RS13940	2675617..2676330	-	714	WP_002381063.1	trehalose operon repressor	-
FGL29_RS13945	2676592..2679336	+	2745	WP_002398920.1	glycoside hydrolase family 65 protein	-
FGL29_RS13950	2679351..2680001	+	651	WP_002354875.1	beta-phosphoglucomutase	-
-	2680251..2680438	+	188	-	-	Antitoxin
FGL29_RS13955	2680371..2680514	-	144	WP_002392696.1	putative holin-like toxin	Toxin
FGL29_RS13960	2681331..2681863	+	533	Protein_2589	CPBP family intramembrane metalloprotease	-
FGL29_RS13965	2681917..2682888	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
FGL29_RS13970	2683063..2683500	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
FGL29_RS13975	2683633..2684187	-	555	WP_002354869.1	septum formation protein Maf	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T288545 WP_002392696.1 NZ_LR594051:c2680514-2680371 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 188 bp

>AT288545 NZ_LR594051:2680251-2680438 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACTTTTT
GAATTATTTAAAAATAACCGTACTCGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGT
GCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin