Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1891843..1892362 Replicon chromosome
Accession NZ_LR594043
Organism Streptococcus suis strain NCTC10237

Toxin (Protein)


Gene name yoeB Uniprot ID A0A4V0ELL3
Locus tag FGL16_RS09940 Protein ID WP_014736467.1
Coordinates 1891843..1892100 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A4V0EL70
Locus tag FGL16_RS09945 Protein ID WP_014736468.1
Coordinates 1892102..1892362 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL16_RS09925 1888311..1890041 - 1731 WP_014736464.1 membrane protein -
FGL16_RS09930 1890404..1891276 - 873 WP_014736465.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
FGL16_RS09935 1891295..1891825 - 531 WP_014736466.1 DUF1697 domain-containing protein -
FGL16_RS09940 1891843..1892100 - 258 WP_014736467.1 Txe/YoeB family addiction module toxin Toxin
FGL16_RS09945 1892102..1892362 - 261 WP_014736468.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FGL16_RS09950 1892438..1892893 - 456 WP_014736469.1 8-oxo-dGTP diphosphatase -
FGL16_RS09955 1892897..1893265 - 369 WP_014736470.1 hypothetical protein -
FGL16_RS09960 1893258..1893825 - 568 Protein_1822 ribonuclease M5 -
FGL16_RS09965 1893809..1894591 - 783 WP_014736471.1 TatD family hydrolase -
FGL16_RS09970 1894698..1894835 - 138 WP_002939016.1 50S ribosomal protein L34 -
FGL16_RS09975 1895003..1895998 - 996 WP_014736472.1 protein jag -
FGL16_RS09980 1896018..1896830 - 813 WP_014736473.1 YidC/Oxa1 family membrane protein insertase -
FGL16_RS09985 1896814..1897173 - 360 WP_014736474.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10309.77 Da        Isoelectric Point: 7.3118

>T288531 WP_014736467.1 NZ_LR594043:c1892100-1891843 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYKGAWSRRIDAENRLIYMVETDQLYILSL
KDHYG

Download         Length: 258 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9931.25 Da        Isoelectric Point: 5.1100

>AT288531 WP_014736468.1 NZ_LR594043:c1892362-1892102 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAQVKAGQTQEH
NLIEAD

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V0ELL3

Antitoxin

Source ID Structure
AlphaFold DB A0A4V0EL70

References