Detailed information of TA system TA288526

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 387813..388325
• Replicon: chromosome
• Accession: NZ_LR594040
• Organism: Streptococcus australis strain NCTC5338

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: FGK98_RS02055
• Protein ID: WP_138099819.1
• Coordinates: 388071..388325 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: FGK98_RS02050
• Protein ID: WP_025171799.1
• Coordinates: 387813..388067 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGK98_RS02020	383686..383997	+	312	WP_000060169.1	ribosome assembly RNA-binding protein YhbY	-
FGK98_RS02025	384049..384678	+	630	WP_000963695.1	nicotinate-nucleotide adenylyltransferase	-
FGK98_RS02030	384678..385271	+	594	WP_138099815.1	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK	-
FGK98_RS02035	385272..385625	+	354	WP_138099816.1	ribosome silencing factor	-
FGK98_RS02040	385773..386573	+	801	WP_138099817.1	class I SAM-dependent methyltransferase	-
FGK98_RS02045	386583..387680	+	1098	WP_138099818.1	nucleotidyltransferase	-
FGK98_RS02050	387813..388067	+	255	WP_025171799.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FGK98_RS02055	388071..388325	+	255	WP_138099819.1	Txe/YoeB family addiction module toxin	Toxin
FGK98_RS09885	388893..389699	+	807	Protein_358	NTPase	-
FGK98_RS09890	389671..390186	+	516	WP_206750892.1	hypothetical protein	-
FGK98_RS02065	390314..391927	+	1614	WP_138099820.1	ribonuclease Y	-
FGK98_RS02070	392062..392688	+	627	WP_049521923.1	guanylate kinase	-
FGK98_RS02075	392713..393027	+	315	WP_002875802.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10129.58 Da
• Isoelectric Point: 7.9716

>T288526 WP_138099819.1 NZ_LR594040:388071-388325 [Streptococcus australis]
MLLKFTEDSWADYCYWQNQDKKTLKRINKLIKDIQRDPFVGMGKPEPLKYDYQGAWSRRIDAENRLIYMIDGDSVAFLSF
KDHY

Nucleotide

• Length: 255 bp

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9675.97 Da
• Isoelectric Point: 4.8430

>AT288526 WP_025171799.1 NZ_LR594040:387813-388067 [Streptococcus australis]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGGTQVH
VIEE

Nucleotide

• Length: 255 bp