Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1951203..1951863 Replicon chromosome
Accession NZ_LR594038
Organism Klebsiella grimontii strain NCTC9146 substr. serovar casular

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FGL39_RS09305 Protein ID WP_049089248.1
Coordinates 1951203..1951556 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A9E1DQ94
Locus tag FGL39_RS09310 Protein ID WP_004132739.1
Coordinates 1951561..1951863 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL39_RS09280 1946587..1947354 - 768 WP_004132727.1 molybdopterin-dependent oxidoreductase -
FGL39_RS09285 1947344..1947952 - 609 WP_004132729.1 cytochrome b/b6 domain-containing protein -
FGL39_RS09290 1947967..1948593 - 627 WP_004132731.1 hypothetical protein -
FGL39_RS09295 1948733..1949401 + 669 WP_004132733.1 heavy metal response regulator transcription factor -
FGL39_RS09300 1949401..1950819 + 1419 WP_049085817.1 heavy metal sensor histidine kinase -
FGL39_RS09305 1951203..1951556 + 354 WP_049089248.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGL39_RS09310 1951561..1951863 + 303 WP_004132739.1 XRE family transcriptional regulator Antitoxin
FGL39_RS09315 1951954..1952127 + 174 WP_101868488.1 helix-turn-helix domain-containing protein -
FGL39_RS09320 1952250..1952453 + 204 Protein_1807 hypothetical protein -
FGL39_RS09325 1952454..1952787 + 334 Protein_1808 type II toxin-antitoxin system PemK/MazF family toxin -
FGL39_RS09330 1953126..1953263 + 138 Protein_1809 patatin -
FGL39_RS09335 1953404..1954285 - 882 WP_064793685.1 hypothetical protein -
FGL39_RS09340 1954694..1954942 + 249 WP_138110103.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13639.64 Da        Isoelectric Point: 9.8874

>T288516 WP_049089248.1 NZ_LR594038:1951203-1951556 [Klebsiella grimontii]
VWMIKTTDTFERWFTSLNDTDRARVLAALLVLREKGPGLSRPYADTLRGSRYSDMKELRIQSRGEPIRAFFAFDPARTGI
VLCAGNKVGNEKRFYDEMLPVAEREFTNWLKTFKEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11072.83 Da        Isoelectric Point: 5.7424

>AT288516 WP_004132739.1 NZ_LR594038:1951561-1951863 [Klebsiella grimontii]
MGRTLEQLMADEKPEVVADARAMAADILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFEL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References