Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-couple_hipB
Location 1279445..1280096 Replicon chromosome
Accession NZ_LR594037
Organism Streptococcus anginosus strain NCTC11064

Toxin (Protein)


Gene name higB Uniprot ID A0A0P0NA83
Locus tag FGK97_RS06335 Protein ID WP_003023734.1
Coordinates 1279731..1280096 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0P0NA18
Locus tag FGK97_RS06330 Protein ID WP_003023736.1
Coordinates 1279445..1279741 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGK97_RS06315 1275014..1275610 - 597 WP_021001926.1 recombination mediator RecR -
FGK97_RS06320 1275621..1277681 - 2061 WP_021001927.1 penicillin-binding protein PBP2B -
FGK97_RS09680 1278044..1278211 - 168 WP_003023739.1 hypothetical protein -
FGK97_RS06325 1278218..1279423 - 1206 WP_003023737.1 hypothetical protein -
FGK97_RS06330 1279445..1279741 - 297 WP_003023736.1 helix-turn-helix transcriptional regulator Antitoxin
FGK97_RS06335 1279731..1280096 - 366 WP_003023734.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGK97_RS06340 1280371..1280550 - 180 WP_106079412.1 hypothetical protein -
FGK97_RS06345 1280888..1281415 + 528 Protein_1208 site-specific integrase -
FGK97_RS06350 1281573..1282265 - 693 WP_003023729.1 phosphoglycerate mutase -
FGK97_RS06355 1282407..1282868 - 462 WP_003031404.1 transcriptional repressor -
FGK97_RS06360 1283045..1283320 - 276 WP_003023726.1 HU family DNA-binding protein -
FGK97_RS06365 1283449..1284282 - 834 WP_003023725.1 DegV family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(35-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-88)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14583.84 Da        Isoelectric Point: 10.1543

>T288512 WP_003023734.1 NZ_LR594037:c1280096-1279731 [Streptococcus anginosus]
VHNIYFYKDKNGNEPVLDYMRELASKKGKDSRIKLNKINDYIELLSQRGTRAGEPYIKHLDAEIWELRPLRDRILFVAWI
DGNFVLLHHFMKKTQKTPKREIEQAKRELRDLKERGLYNEK

Download         Length: 366 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10699.35 Da        Isoelectric Point: 4.8780

>AT288512 WP_003023736.1 NZ_LR594037:c1279741-1279445 [Streptococcus anginosus]
MKNSAIGSNWKDVRAELFSKEEILESDMRVAIMSELIDARNEKGISQKKLEELSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEGEQVS

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0NA83

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0NA18

References