Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 4560167..4560771 Replicon chromosome
Accession NZ_LR590482
Organism Pseudomonas synxantha strain NCTC10696

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FGL41_RS21100 Protein ID WP_057022036.1
Coordinates 4560167..4560481 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FGL41_RS21105 Protein ID WP_057022035.1
Coordinates 4560484..4560771 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL41_RS21080 4555230..4556267 - 1038 WP_057022040.1 histone deacetylase family protein -
FGL41_RS21085 4556402..4557634 - 1233 WP_057022039.1 Zn-dependent hydrolase -
FGL41_RS21090 4557646..4558962 - 1317 WP_057022038.1 MHS family MFS transporter -
FGL41_RS21095 4559120..4560061 + 942 WP_057022037.1 LysR family transcriptional regulator -
FGL41_RS21100 4560167..4560481 + 315 WP_057022036.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGL41_RS21105 4560484..4560771 + 288 WP_057022035.1 helix-turn-helix domain-containing protein Antitoxin
FGL41_RS21110 4561011..4562237 + 1227 WP_057022034.1 MFS transporter -
FGL41_RS21115 4562312..4562566 - 255 WP_057022033.1 hypothetical protein -
FGL41_RS21125 4563220..4563459 + 240 WP_014717442.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
FGL41_RS21130 4563449..4563742 + 294 WP_057022032.1 type II toxin-antitoxin system RelE/ParE family toxin -
FGL41_RS21140 4564011..4564724 - 714 WP_057022031.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
FGL41_RS21145 4564752..4565510 - 759 WP_056847351.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(16-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11656.44 Da        Isoelectric Point: 9.8054

>T288495 WP_057022036.1 NZ_LR590482:4560167-4560481 [Pseudomonas synxantha]
MIFIETSVFTRRVKELIDEDAYTALQNVLVVNPSAGDVIEGTGGVRKIRVAAKGHGKRGGARVIYYHFVSASQIVLLMIY
PKNEQQDLTADERKSLKAAIEHWR

Download         Length: 315 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10827.42 Da        Isoelectric Point: 8.8454

>AT288495 WP_057022035.1 NZ_LR590482:4560484-4560771 [Pseudomonas synxantha]
MSRFFNELMESVQEMNEILRGEREPSREFHVDSMRVKEIRKATGLTQAKFAALIDVQLGTLRNWEQGRREPTGPAKALLK
AIHNDPVHVLNALAS

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References