Detailed information of TA system TA028849

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 4281979..4282631
• Replicon: chromosome
• Accession: NC_020211
• Organism: Serratia marcescens WW4

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: SMWW4_RS19965
• Protein ID: WP_015378926.1
• Coordinates: 4281979..4282323 (+)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A086GAN0
• Locus tag: SMWW4_RS19970
• Protein ID: WP_004931828.1
• Coordinates: 4282329..4282631 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMWW4_RS19955	4278320..4280578	-	2259	WP_004931835.1	molybdopterin guanine dinucleotide-containing S/N-oxide reductase	-
SMWW4_RS19960	4280800..4281819	+	1020	WP_004931832.1	HTH-type transcriptional regulator GalR	-
SMWW4_RS19965	4281979..4282323	+	345	WP_015378926.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SMWW4_RS19970	4282329..4282631	+	303	WP_004931828.1	helix-turn-helix transcriptional regulator	Antitoxin
SMWW4_RS19975	4282659..4283921	-	1263	WP_004931826.1	diaminopimelate decarboxylase	-
SMWW4_RS19980	4284055..4284978	+	924	WP_015378927.1	LysR family transcriptional regulator	-
SMWW4_RS19985	4285006..4285914	-	909	WP_015378928.1	LysR family transcriptional regulator	-
SMWW4_RS19990	4286023..4286907	+	885	WP_015378929.1	MBL fold metallo-hydrolase	-
SMWW4_RS19995	4286976..4287623	+	648	WP_015378930.1	DsbA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-85)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13335.40 Da
• Isoelectric Point: 10.6087

>T28849 WP_015378926.1 NC_020211:4281979-4282323 [Serratia marcescens WW4]
MWQVVTVERFDDWFLALNNAQQTSILAAIYKLQTFGPQLARPHADTLHFSDAVRQLKELRIQHRGRPFRVVFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Nucleotide

• Length: 345 bp

>T28849 NC_020211:4281979-4282323 [Serratia marcescens WW4]
ATGTGGCAAGTGGTGACCGTCGAACGGTTTGACGACTGGTTTTTGGCGCTCAACAACGCCCAGCAAACAAGCATCCTGGC
GGCGATCTACAAATTGCAGACGTTCGGTCCGCAATTGGCGCGGCCGCATGCCGATACGCTGCATTTTTCCGACGCGGTCC
GGCAGTTGAAGGAGCTGCGCATTCAACATCGCGGGCGCCCTTTCAGGGTGGTTTTCGCCTTTGATCCACAGCGGCAAGCG
GTATTGCTGTGCGGCGGCGATAAAACCGGCGACAAACGCTTTTACCAGCGCATGTTGCCCATCGCCGCCATGGAGTTTTC
ACATTATCTGGCAACCCGGAGGTAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11080.97 Da
• Isoelectric Point: 10.1998

>AT28849 WP_004931828.1 NC_020211:4282329-4282631 [Serratia marcescens WW4]
MAKPLSQLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Nucleotide

• Length: 303 bp

>AT28849 NC_020211:4282329-4282631 [Serratia marcescens WW4]
ATGGCCAAACCTTTATCCCAACTGATCGATAAACTCGATCCCGCCGTCGTTGCCGCCGCCAGGCAAAAAGCGGACCAGGA
GATTTTCGAGCTGCGGCTGGCGATGCTGAGGGAAGAGTTGGCGGTTTCTCAGGTTGAATTGGCGAAGCGGCTCGGCATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATCAAACTGTCGTCGCTCAAACGCTATATCGAGGCGATG
GGCGGCACGCTGTCGCTGGATGTGCAATTGCCCAATGGCCAGCACCGCCGCATGACACTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A086GAN0