288464

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 317662..319010 Replicon chromosome
Accession NZ_LR590465
Organism Haemophilus influenzae strain NCTC8468

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag FGK83_RS01610 Protein ID WP_138171499.1
Coordinates 317979..319010 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag FGK83_RS01605 Protein ID WP_138171498.1
Coordinates 317662..317982 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGK83_RS01565 313071..313349 + 279 WP_005658968.1 cell division protein FtsB -
FGK83_RS01570 313349..314026 + 678 WP_138171496.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
FGK83_RS01575 314023..314499 + 477 WP_048942806.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
FGK83_RS01580 314811..315245 - 435 WP_118807115.1 D-tyrosyl-tRNA(Tyr) deacylase -
FGK83_RS01585 315242..315682 - 441 WP_050948953.1 FMN-binding protein MioC -
FGK83_RS01590 315780..315998 - 219 WP_005650820.1 cell division protein ZapB -
FGK83_RS01595 316160..317161 + 1002 WP_050948954.1 class II fructose-bisphosphatase -
FGK83_RS01600 317366..317674 + 309 WP_138171497.1 helix-turn-helix domain-containing protein -
FGK83_RS01605 317662..317982 + 321 WP_138171498.1 type II toxin-antitoxin system HipA family toxin Antitoxin
FGK83_RS01610 317979..319010 + 1032 WP_138171499.1 type II toxin-antitoxin system HipA family toxin Toxin
FGK83_RS01615 319093..320751 - 1659 WP_138171500.1 thiol reductant ABC exporter subunit CydC -
FGK83_RS01620 320744..322489 - 1746 WP_138171501.1 ABC transporter ATP-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39816.31 Da        Isoelectric Point: 6.5050

>T288464 WP_138171499.1 NZ_LR590465:317979-319010 [Haemophilus influenzae]
MNFCRILLKPLKKNEVHSGYSTKGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDDHFDSVDQQ
GHYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNQKEFAFVIKRFDRDEQQKPVHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQQEIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
ETFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLTLLNVLNEPEL

Download         Length: 1032 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12427.08 Da        Isoelectric Point: 5.9670

>AT288464 WP_138171498.1 NZ_LR590465:317662-317982 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFAYNSDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
ESDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References