Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3523695..3524355 Replicon chromosome
Accession NC_020211
Organism Serratia marcescens WW4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag SMWW4_RS16475 Protein ID WP_015378478.1
Coordinates 3524002..3524355 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag SMWW4_RS16470 Protein ID WP_015378477.1
Coordinates 3523695..3523997 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMWW4_RS16445 3519248..3519982 - 735 WP_015378473.1 SDR family oxidoreductase -
SMWW4_RS16450 3520019..3520654 - 636 WP_015378474.1 SDR family oxidoreductase -
SMWW4_RS16455 3520670..3521605 - 936 WP_015378475.1 alpha/beta hydrolase -
SMWW4_RS16460 3521605..3522525 - 921 WP_031300707.1 alpha/beta hydrolase -
SMWW4_RS16465 3522664..3523572 + 909 WP_004935498.1 LysR family transcriptional regulator -
SMWW4_RS16470 3523695..3523997 - 303 WP_015378477.1 XRE family transcriptional regulator Antitoxin
SMWW4_RS16475 3524002..3524355 - 354 WP_015378478.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SMWW4_RS16480 3524792..3526087 + 1296 WP_004935508.1 MFS transporter -
SMWW4_RS16485 3526114..3526920 + 807 WP_015378479.1 substrate-binding domain-containing protein -
SMWW4_RS16490 3526895..3527794 - 900 WP_015378480.1 LysR family transcriptional regulator -
SMWW4_RS16495 3527899..3528264 - 366 WP_004935528.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13595.58 Da        Isoelectric Point: 9.0493

>T28846 WP_015378478.1 NC_020211:c3524355-3524002 [Serratia marcescens WW4]
VWEIKTTDAFDHWFRSLSDADRACVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRVGM
VLCAGNKAGDEKRFYDRMLQIADREFTNWLNTLKEKE

Download         Length: 354 bp

>T28846 NC_020211:c3524355-3524002 [Serratia marcescens WW4]
GTGTGGGAAATTAAAACAACGGATGCATTTGATCATTGGTTCAGATCACTCAGCGATGCCGACCGGGCCTGCGTGCTTGC
TGCATTGATGGTCCTGCGGGAAAAAGGGCCCGGCTTGCCCAGACCCTATGCCGATACGGTTAAAGGCTCGCGTTACAGCA
ACATGAAAGAGCTGCGTATTCAGAGCCGTGGCGAACCGTTGCGGGCATTCTTCGCCTTCGATCCGTACCGCGTCGGCATG
GTGCTTTGCGCGGGCAATAAAGCGGGCGATGAAAAACGTTTTTACGATCGAATGCTGCAGATTGCCGATCGGGAATTCAC
GAATTGGCTGAACACACTAAAAGAGAAGGAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11171.02 Da        Isoelectric Point: 5.1992

>AT28846 WP_015378477.1 NC_020211:c3523997-3523695 [Serratia marcescens WW4]
MGRTLEQLIAEEKPEVVAEAQAMATDIMLNIHLAELREKVQKTQVEMAQVLGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp

>AT28846 NC_020211:c3523997-3523695 [Serratia marcescens WW4]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGAGGAAAAGCCCGAGGTCGTGGCCGAAGCGCAGGCAATGGCGACGGACAT
TATGCTGAACATCCATCTTGCCGAGCTGCGCGAGAAGGTGCAGAAAACCCAGGTTGAAATGGCGCAGGTGCTGGGTATCC
GGCAACCGACCGTCGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTTAAACGCTATGTTGAGGCGGCC
GGCGGCAAACTGCGCCTGGATGTCGAACTGCCGGACGGTTCGCACTACGAATTTGTGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References