Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3741202..3741799 Replicon chromosome
Accession NZ_LR588412
Organism Klebsiella pneumoniae strain NCTC9157

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag FGL27_RS18350 Protein ID WP_004142563.1
Coordinates 3741482..3741799 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag FGL27_RS18345 Protein ID WP_004142561.1
Coordinates 3741202..3741489 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL27_RS18315 3737282..3737530 + 249 WP_002893037.1 DUF1158 domain-containing protein -
FGL27_RS18320 3737548..3737889 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
FGL27_RS18325 3737920..3739035 - 1116 WP_012737592.1 MBL fold metallo-hydrolase -
FGL27_RS18330 3739215..3739796 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
FGL27_RS18335 3739796..3740164 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
FGL27_RS18340 3740284..3740937 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
FGL27_RS18345 3741202..3741489 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
FGL27_RS18350 3741482..3741799 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGL27_RS18355 3741984..3743027 - 1044 WP_102008192.1 DUF2157 domain-containing protein -
FGL27_RS18360 3743697..3744563 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
FGL27_RS18365 3744672..3746099 + 1428 WP_138074422.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T288457 WP_004142563.1 NZ_LR588412:c3741799-3741482 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT288457 WP_004142561.1 NZ_LR588412:c3741489-3741202 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References