Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 355076..355722 Replicon chromosome
Accession NZ_LR588412
Organism Klebsiella pneumoniae strain NCTC9157

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag FGL27_RS01650 Protein ID WP_016529833.1
Coordinates 355076..355423 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1F2LZT5
Locus tag FGL27_RS01655 Protein ID WP_008806992.1
Coordinates 355423..355722 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL27_RS01640 351002..352435 + 1434 WP_002920564.1 glycogen synthase GlgA -
FGL27_RS01645 352453..354900 + 2448 WP_087759684.1 glycogen phosphorylase -
FGL27_RS01650 355076..355423 + 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGL27_RS01655 355423..355722 + 300 WP_008806992.1 helix-turn-helix transcriptional regulator Antitoxin
FGL27_RS01660 355785..357293 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
FGL27_RS01665 357498..357827 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
FGL27_RS01670 357878..358708 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
FGL27_RS01675 358758..359525 + 768 WP_138074149.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T288450 WP_016529833.1 NZ_LR588412:355076-355423 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10814.61 Da        Isoelectric Point: 10.1464

>AT288450 WP_008806992.1 NZ_LR588412:355423-355722 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2LZT5

References