Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1472007..1472519 Replicon chromosome
Accession NZ_LR536843
Organism Streptococcus pneumoniae strain GPSC55 substr. ST3774 isolate b04a6400-1f66-11e7-b93e-3c4a9275d6c8

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag E0F34_RS07970 Protein ID WP_000924721.1
Coordinates 1472007..1472261 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag E0F34_RS07975 Protein ID WP_000388572.1
Coordinates 1472265..1472519 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0F34_RS07955 1469108..1469422 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
E0F34_RS07960 1469447..1470073 - 627 WP_000775037.1 guanylate kinase -
E0F34_RS07965 1470203..1471816 - 1614 WP_000404940.1 ribonuclease Y -
E0F34_RS07970 1472007..1472261 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
E0F34_RS07975 1472265..1472519 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E0F34_RS07980 1472757..1473854 - 1098 WP_050122521.1 nucleotidyltransferase -
E0F34_RS07985 1473864..1474610 - 747 WP_000605159.1 class I SAM-dependent methyltransferase -
E0F34_RS07990 1474713..1475066 - 354 WP_050122523.1 ribosome silencing factor -
E0F34_RS07995 1475079..1475579 - 501 WP_000844707.1 cysteine hydrolase -
E0F34_RS08000 1475580..1476173 - 594 WP_050122526.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
E0F34_RS08005 1476173..1476802 - 630 WP_000151307.1 nicotinate-nucleotide adenylyltransferase -
E0F34_RS08010 1476854..1477165 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T288423 WP_000924721.1 NZ_LR536843:c1472261-1472007 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT288423 WP_000388572.1 NZ_LR536843:c1472519-1472265 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References