Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4095975..4096516 Replicon chromosome
Accession NZ_LR536431
Organism Escherichia coli isolate f9610206-5e81-11e8-bf7f-3c4a9275d6c8

Toxin (Protein)


Gene name yafQ Uniprot ID S1FHQ9
Locus tag E4Z82_RS20545 Protein ID WP_000615979.1
Coordinates 4096238..4096516 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag E4Z82_RS20540 Protein ID WP_000729704.1
Coordinates 4095975..4096235 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4Z82_RS20515 4091758..4092543 - 786 WP_000207573.1 putative lateral flagellar export/assembly protein LafU -
E4Z82_RS20520 4092515..4094227 + 1713 Protein_3950 flagellar biosynthesis protein FlhA -
E4Z82_RS20525 4094332..4094610 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
E4Z82_RS20530 4094603..4094959 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
E4Z82_RS20535 4095016..4095789 - 774 WP_000543902.1 C40 family peptidase -
E4Z82_RS20540 4095975..4096235 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
E4Z82_RS20545 4096238..4096516 + 279 WP_000615979.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
E4Z82_RS20550 4096672..4097412 + 741 WP_001225679.1 murein L,D-transpeptidase -
E4Z82_RS20555 4097383..4098150 - 768 WP_001365365.1 class II glutamine amidotransferase -
E4Z82_RS20560 4098356..4098934 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T288418 WP_000615979.1 NZ_LR536431:4096238-4096516 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT288418 WP_000729704.1 NZ_LR536431:4095975-4096235 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1FHQ9

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References