Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 730918..731645 Replicon chromosome
Accession NZ_LR536431
Organism Escherichia coli isolate f9610206-5e81-11e8-bf7f-3c4a9275d6c8

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag E4Z82_RS03630 Protein ID WP_000550189.1
Coordinates 730918..731232 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E4Z82_RS03635 Protein ID WP_000560263.1
Coordinates 731229..731645 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4Z82_RS03610 727084..728070 - 987 WP_001446103.1 Gfo/Idh/MocA family oxidoreductase -
E4Z82_RS03615 728149..728832 - 684 WP_001183037.1 vancomycin high temperature exclusion protein -
E4Z82_RS03620 728909..729412 - 504 WP_001295542.1 M48 family metallopeptidase -
E4Z82_RS03625 729497..730633 + 1137 WP_000018685.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
E4Z82_RS03630 730918..731232 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
E4Z82_RS03635 731229..731645 + 417 WP_000560263.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
E4Z82_RS03640 731690..733708 - 2019 WP_000121448.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
E4Z82_RS03645 734134..736485 - 2352 WP_032175665.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T288405 WP_000550189.1 NZ_LR536431:730918-731232 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14979.42 Da        Isoelectric Point: 4.4547

>AT288405 WP_000560263.1 NZ_LR536431:731229-731645 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLADLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References