Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 671963..672762 Replicon chromosome
Accession NZ_LR536431
Organism Escherichia coli isolate f9610206-5e81-11e8-bf7f-3c4a9275d6c8

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag E4Z82_RS03345 Protein ID WP_000347251.1
Coordinates 671963..672427 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag E4Z82_RS03350 Protein ID WP_001307405.1
Coordinates 672427..672762 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4Z82_RS03315 666964..667398 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
E4Z82_RS03320 667416..668294 - 879 WP_001445991.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
E4Z82_RS03325 668284..669063 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
E4Z82_RS03330 669074..669547 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
E4Z82_RS03335 669570..670850 - 1281 WP_024262621.1 tagatose-bisphosphate aldolase subunit KbaZ -
E4Z82_RS03340 671099..671908 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
E4Z82_RS03345 671963..672427 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
E4Z82_RS03350 672427..672762 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
E4Z82_RS03355 672911..674482 - 1572 WP_023063023.1 galactarate dehydratase -
E4Z82_RS03360 674857..676191 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
E4Z82_RS03365 676207..676977 + 771 WP_023063022.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T288404 WP_000347251.1 NZ_LR536431:c672427-671963 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT288404 WP_001307405.1 NZ_LR536431:c672762-672427 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References