Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4919978..4920480 Replicon chromosome
Accession NZ_LR536430
Organism Escherichia coli isolate f974b26a-5e81-11e8-bf7f-3c4a9275d6c8

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag E4Z69_RS24165 Protein ID WP_000767829.1
Coordinates 4920226..4920480 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag E4Z69_RS24160 Protein ID WP_001259255.1
Coordinates 4919978..4920229 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4Z69_RS24135 4915156..4916223 - 1068 WP_000080136.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
E4Z69_RS24140 4916223..4917293 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
E4Z69_RS24145 4917296..4918594 - 1299 WP_063074566.1 histidinol dehydrogenase -
E4Z69_RS24150 4918600..4919499 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
E4Z69_RS24155 4919645..4919695 - 51 WP_001364200.1 his operon leader peptide -
E4Z69_RS24160 4919978..4920229 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
E4Z69_RS24165 4920226..4920480 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
E4Z69_RS24170 4920563..4921387 + 825 WP_000754762.1 SDR family oxidoreductase -
E4Z69_RS24175 4921433..4922362 + 930 WP_000803360.1 LysR family transcriptional regulator -
E4Z69_RS24180 4922577..4922639 + 63 WP_010723108.1 membrane protein YoeI -
E4Z69_RS24185 4922629..4923987 + 1359 WP_077483161.1 putrescine/proton symporter PlaP -
E4Z69_RS24190 4924166..4925224 + 1059 WP_000492305.1 transport protein YeeE -
E4Z69_RS24195 4925238..4925465 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - wza / gmd / wcaG / manB / wcaJ / galF / gmd / fcl / manC / manB / gnd / ugd 4777456..4972255 194799


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T288401 WP_000767829.1 NZ_LR536430:4920226-4920480 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT288401 WP_001259255.1 NZ_LR536430:4919978-4920229 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References