Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1728142..1728835 Replicon chromosome
Accession NZ_LR536430
Organism Escherichia coli isolate f974b26a-5e81-11e8-bf7f-3c4a9275d6c8

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag E4Z69_RS08820 Protein ID WP_000415584.1
Coordinates 1728539..1728835 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag E4Z69_RS08815 Protein ID WP_000650107.1
Coordinates 1728142..1728537 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4Z69_RS08805 1724006..1726264 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
E4Z69_RS08810 1726402..1728009 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
E4Z69_RS08815 1728142..1728537 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
E4Z69_RS08820 1728539..1728835 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
E4Z69_RS08825 1729040..1729522 - 483 WP_000609258.1 GyrI-like domain-containing protein -
E4Z69_RS08830 1729575..1729967 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
E4Z69_RS08835 1730119..1730778 + 660 WP_001221493.1 two-component system response regulator QseB -
E4Z69_RS08840 1730775..1732124 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
E4Z69_RS08845 1732170..1732502 - 333 WP_000914691.1 DUF2645 family protein -
E4Z69_RS08850 1732509..1733701 - 1193 Protein_1705 Hcp family type VI secretion system effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T288389 WP_000415584.1 NZ_LR536430:c1728835-1728539 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT288389 WP_000650107.1 NZ_LR536430:c1728537-1728142 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References