Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3395114..3395616 Replicon chromosome
Accession NZ_LR217818
Organism Escherichia coli strain NCTC86

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag E4V11_RS16830 Protein ID WP_000767829.1
Coordinates 3395114..3395368 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag E4V11_RS16835 Protein ID WP_001259255.1
Coordinates 3395365..3395616 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4V11_RS16800 3390129..3390356 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
E4V11_RS16805 3390370..3391428 - 1059 WP_000492305.1 transport protein YeeE -
E4V11_RS16810 3391607..3392965 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
E4V11_RS16815 3392955..3393017 - 63 WP_010723108.1 membrane protein YoeI -
E4V11_RS16820 3393232..3394161 - 930 WP_000803360.1 LysR family transcriptional regulator -
E4V11_RS16825 3394207..3395031 - 825 WP_000754762.1 SDR family oxidoreductase -
E4V11_RS16830 3395114..3395368 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
E4V11_RS16835 3395365..3395616 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
E4V11_RS16840 3395899..3395949 + 51 WP_001364200.1 his operon leader peptide -
E4V11_RS16845 3396095..3396994 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
E4V11_RS16850 3397000..3398298 + 1299 WP_001743908.1 histidinol dehydrogenase -
E4V11_RS16855 3398301..3399371 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
E4V11_RS16860 3399371..3400438 + 1068 WP_000080136.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T288367 WP_000767829.1 NZ_LR217818:c3395368-3395114 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT288367 WP_001259255.1 NZ_LR217818:c3395616-3395365 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References