Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 747921..748614 Replicon chromosome
Accession NZ_LR217818
Organism Escherichia coli strain NCTC86

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag E4V11_RS03600 Protein ID WP_000415584.1
Coordinates 747921..748217 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag E4V11_RS03605 Protein ID WP_000650107.1
Coordinates 748219..748614 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4V11_RS03565 743009..743323 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
E4V11_RS03570 743354..743935 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
E4V11_RS03575 744254..744586 + 333 WP_000917684.1 DUF2645 family protein -
E4V11_RS03580 744632..745981 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
E4V11_RS03585 745978..746637 - 660 WP_001221493.1 two-component system response regulator QseB -
E4V11_RS03590 746789..747181 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
E4V11_RS03595 747234..747716 + 483 WP_000183505.1 transcriptional regulator -
E4V11_RS03600 747921..748217 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
E4V11_RS03605 748219..748614 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
E4V11_RS03610 748747..750354 + 1608 WP_021561146.1 ABC transporter substrate-binding protein -
E4V11_RS03615 750492..752750 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - rfaE / gspK / gspL / gspM / kpsM / kpsT / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF / draA 716973..865741 148768


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T288346 WP_000415584.1 NZ_LR217818:747921-748217 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT288346 WP_000650107.1 NZ_LR217818:748219-748614 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References