Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1574849..1575361 Replicon chromosome
Accession NZ_LR216065
Organism Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag E0F40_RS08310 Protein ID WP_000924721.1
Coordinates 1574849..1575103 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag E0F40_RS08315 Protein ID WP_000388572.1
Coordinates 1575107..1575361 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0F40_RS08295 1571950..1572264 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
E0F40_RS08300 1572289..1572915 - 627 WP_000775037.1 guanylate kinase -
E0F40_RS08305 1573045..1574658 - 1614 WP_000404940.1 ribonuclease Y -
E0F40_RS08310 1574849..1575103 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
E0F40_RS08315 1575107..1575361 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E0F40_RS08320 1575599..1576696 - 1098 WP_000156330.1 nucleotidyltransferase -
E0F40_RS08325 1576706..1577452 - 747 WP_000605157.1 class I SAM-dependent methyltransferase -
E0F40_RS08330 1577555..1577908 - 354 WP_001003001.1 ribosome silencing factor -
E0F40_RS08335 1577921..1578421 - 501 WP_000844713.1 cysteine hydrolase -
E0F40_RS08340 1578422..1579015 - 594 WP_000121650.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
E0F40_RS08345 1579015..1579644 - 630 WP_000151313.1 nicotinate-nucleotide adenylyltransferase -
E0F40_RS08350 1579696..1580007 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T288342 WP_000924721.1 NZ_LR216065:c1575103-1574849 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT288342 WP_000388572.1 NZ_LR216065:c1575361-1575107 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References