288336

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1693939..1694451 Replicon chromosome
Accession NZ_LR216060
Organism Streptococcus pneumoniae strain GPSC47 substr. ST315

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag E0F39_RS09055 Protein ID WP_000924721.1
Coordinates 1693939..1694193 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B7LSG7
Locus tag E0F39_RS09060 Protein ID WP_000388571.1
Coordinates 1694197..1694451 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0F39_RS09040 1691040..1691354 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
E0F39_RS09045 1691379..1692005 - 627 WP_000775037.1 guanylate kinase -
E0F39_RS09050 1692135..1693748 - 1614 WP_000404929.1 ribonuclease Y -
E0F39_RS09055 1693939..1694193 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
E0F39_RS09060 1694197..1694451 - 255 WP_000388571.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E0F39_RS09065 1694689..1695786 - 1098 WP_001864735.1 nucleotidyltransferase -
E0F39_RS09070 1695796..1696542 - 747 WP_000605167.1 class I SAM-dependent methyltransferase -
E0F39_RS09075 1696645..1696998 - 354 WP_001003001.1 ribosome silencing factor -
E0F39_RS09080 1697011..1697511 - 501 WP_000844718.1 cysteine hydrolase -
E0F39_RS09085 1697512..1698105 - 594 WP_000121660.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
E0F39_RS09090 1698105..1698734 - 630 WP_001864736.1 nicotinate-nucleotide adenylyltransferase -
E0F39_RS09095 1698786..1699097 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T288336 WP_000924721.1 NZ_LR216060:c1694193-1693939 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9718.05 Da        Isoelectric Point: 4.8430

>AT288336 WP_000388571.1 NZ_LR216060:c1694451-1694197 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSIQVH
VIEE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB A0A0B7LSG7

References