Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1584377..1584889 Replicon chromosome
Accession NZ_LR216050
Organism Streptococcus pneumoniae strain GPSC10 substr. ST2013 isolate GPS_US_PATH396-sc-2296505

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag E0F32_RS08460 Protein ID WP_000924721.1
Coordinates 1584377..1584631 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag E0F32_RS08465 Protein ID WP_000388572.1
Coordinates 1584635..1584889 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0F32_RS08445 1581478..1581792 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
E0F32_RS08450 1581817..1582443 - 627 WP_000775037.1 guanylate kinase -
E0F32_RS08455 1582573..1584186 - 1614 WP_000404940.1 ribonuclease Y -
E0F32_RS08460 1584377..1584631 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
E0F32_RS08465 1584635..1584889 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E0F32_RS08470 1585127..1586224 - 1098 WP_130885960.1 nucleotidyltransferase -
E0F32_RS08475 1586234..1586974 - 741 WP_050203050.1 class I SAM-dependent methyltransferase -
E0F32_RS08480 1587083..1587436 - 354 WP_001003000.1 ribosome silencing factor -
E0F32_RS08485 1587449..1587949 - 501 WP_000844717.1 cysteine hydrolase -
E0F32_RS08490 1587950..1588543 - 594 WP_000121662.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
E0F32_RS08495 1588543..1589172 - 630 WP_000151307.1 nicotinate-nucleotide adenylyltransferase -
E0F32_RS08500 1589224..1589535 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T288332 WP_000924721.1 NZ_LR216050:c1584631-1584377 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT288332 WP_000388572.1 NZ_LR216050:c1584889-1584635 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References