288324

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3473940..3474634 Replicon chromosome
Accession NZ_LR215973
Organism Nocardia cyriacigeorgica strain 3012STDY6756504

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag E0E67_RS16025 Protein ID WP_130917663.1
Coordinates 3474269..3474634 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E0E67_RS16020 Protein ID WP_130917662.1
Coordinates 3473940..3474272 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E67_RS16005 3470131..3471078 + 948 WP_130917660.1 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase -
E0E67_RS29460 3471239..3472729 + 1491 WP_197731549.1 serine/threonine protein kinase -
E0E67_RS16015 3472705..3473922 + 1218 WP_130917661.1 hypothetical protein -
E0E67_RS16020 3473940..3474272 - 333 WP_130917662.1 helix-turn-helix domain-containing protein Antitoxin
E0E67_RS16025 3474269..3474634 - 366 WP_130917663.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E0E67_RS16030 3474703..3476130 - 1428 WP_197731550.1 acyl-CoA synthetase -
E0E67_RS16035 3476298..3477149 + 852 WP_130917664.1 DUF2236 domain-containing protein -
E0E67_RS16040 3477170..3477796 - 627 WP_036539457.1 TetR/AcrR family transcriptional regulator -
E0E67_RS16045 3477928..3478788 + 861 WP_197731551.1 DUF2236 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(24-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-97)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13576.26 Da        Isoelectric Point: 4.6636

>T288324 WP_130917663.1 NZ_LR215973:c3474634-3474269 [Nocardia cyriacigeorgica]
VNWEVVLHSEVESWYLAVCVSDPETGDLIEDALDQLAAEGPAAGRPLVDRIKGSEFHNMKELRPPSSGTSEVRMLFAFDP
ARQVIVLVAGDKSGNWQGWYREAIRLADKRFAEHLAAREER

Download         Length: 366 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12005.49 Da        Isoelectric Point: 9.7706

>AT288324 WP_130917662.1 NZ_LR215973:c3474272-3473940 [Nocardia cyriacigeorgica]
MSSEFVKWSDTKAKARALDSRTEAERAEGRARARDRREAYVRGHQLAEMRQSAGLTQVELAELLGVSQARVSKIESGEVS
GIDTIRAYVGALGGTVDVVVTLGDRSWRVA

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References