288305

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4144653..4145380 Replicon chromosome
Accession NZ_LR213458
Organism Shigella sonnei strain AUSMDU00008333 isolate AUSMDU00008333

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag E0E38_RS21025 Protein ID WP_000550189.1
Coordinates 4144653..4144967 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E0E38_RS21030 Protein ID WP_000560263.1
Coordinates 4144964..4145380 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E38_RS21005 (4140819) 4140819..4141805 - 987 WP_001446103.1 Gfo/Idh/MocA family oxidoreductase -
E0E38_RS21010 (4141884) 4141884..4142567 - 684 WP_001183060.1 vancomycin high temperature exclusion protein -
E0E38_RS21015 (4142644) 4142644..4143147 - 504 WP_001305117.1 M48 family metallopeptidase -
E0E38_RS21020 (4143232) 4143232..4144368 + 1137 WP_000018685.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
E0E38_RS21025 (4144653) 4144653..4144967 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
E0E38_RS21030 (4144964) 4144964..4145380 + 417 WP_000560263.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
E0E38_RS21035 (4145425) 4145425..4147443 - 2019 WP_000121451.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
E0E38_RS21040 (4147669) 4147669..4150020 - 2352 Protein_4048 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T288305 WP_000550189.1 NZ_LR213458:4144653-4144967 [Shigella sonnei]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14979.42 Da        Isoelectric Point: 4.4547

>AT288305 WP_000560263.1 NZ_LR213458:4144964-4145380 [Shigella sonnei]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLADLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References