Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3869008..3869735 Replicon chromosome
Accession NZ_LR213458
Organism Shigella sonnei strain AUSMDU00008333 isolate AUSMDU00008333

Toxin (Protein)


Gene name higB Uniprot ID Q3YYE6
Locus tag E0E38_RS19640 Protein ID WP_000547563.1
Coordinates 3869424..3869735 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E0E38_RS19635 Protein ID WP_000126296.1
Coordinates 3869008..3869427 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E38_RS19615 (3864059) 3864059..3864586 - 528 WP_001078766.1 electron transport protein HydN -
E0E38_RS19620 (3864734) 3864734..3865744 - 1011 WP_001402444.1 DNA-binding transcriptional regulator AscG -
E0E38_RS19625 (3866004) 3866004..3867461 + 1458 WP_001107890.1 PTS cellobiose/arbutin/salicin transporter subunit IIBC -
E0E38_RS19630 (3867470) 3867470..3868894 + 1425 WP_000110319.1 6-phospho-beta-glucosidase AscB -
E0E38_RS19635 (3869008) 3869008..3869427 - 420 WP_000126296.1 helix-turn-helix domain-containing protein Antitoxin
E0E38_RS19640 (3869424) 3869424..3869735 - 312 WP_000547563.1 type II toxin-antitoxin system HigB family toxin Toxin
E0E38_RS19645 (3869897) 3869897..3870670 - 774 WP_001026444.1 hypothetical protein -
E0E38_RS19650 (3870695) 3870695..3871165 - 471 WP_000132961.1 hydrogenase maturation peptidase HycI -
E0E38_RS19655 (3871158) 3871158..3871568 - 411 WP_001291918.1 formate hydrogenlyase assembly protein HycH -
E0E38_RS19660 (3871565) 3871565..3872332 - 768 WP_000067403.1 formate hydrogenlyase subunit HycG -
E0E38_RS19665 (3872332) 3872332..3872874 - 543 WP_000493785.1 formate hydrogenlyase subunit HycF -
E0E38_RS19670 (3872884) 3872884..3874581 - 1698 WP_001288143.1 formate hydrogenlyase subunit HycE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12398.11 Da        Isoelectric Point: 9.7105

>T288302 WP_000547563.1 NZ_LR213458:c3869735-3869424 [Shigella sonnei]
MHIISKAPFEESARKYPNDALALQALYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15416.38 Da        Isoelectric Point: 4.3653

>AT288302 WP_000126296.1 NZ_LR213458:c3869427-3869008 [Shigella sonnei]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNQEFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QA22

Antitoxin

Source ID Structure

References