288301

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3063131..3063633 Replicon chromosome
Accession NZ_LR213458
Organism Shigella sonnei strain AUSMDU00008333 isolate AUSMDU00008333

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag E0E38_RS15540 Protein ID WP_000767829.1
Coordinates 3063131..3063385 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag E0E38_RS15545 Protein ID WP_001259255.1
Coordinates 3063382..3063633 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E38_RS15510 (3058146) 3058146..3058373 - 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -
E0E38_RS15515 (3058387) 3058387..3059445 - 1059 WP_000492295.1 thiosulfate utilization transporter TsuA/YeeE -
E0E38_RS15520 (3059624) 3059624..3060982 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
E0E38_RS15525 (3060972) 3060972..3061034 - 63 WP_010723108.1 membrane protein YoeI -
E0E38_RS15530 (3061249) 3061249..3062178 - 930 WP_000811606.1 LysR substrate-binding domain-containing protein -
E0E38_RS15535 (3062224) 3062224..3063048 - 825 WP_000754737.1 SDR family oxidoreductase -
E0E38_RS15540 (3063131) 3063131..3063385 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
E0E38_RS15545 (3063382) 3063382..3063633 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
E0E38_RS15550 (3063916) 3063916..3063966 + 51 WP_001364200.1 his operon leader peptide -
E0E38_RS15555 (3064112) 3064112..3065011 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
E0E38_RS15560 (3065017) 3065017..3066321 + 1305 WP_001462576.1 histidinol dehydrogenase -
E0E38_RS15565 (3066318) 3066318..3067388 + 1071 WP_039063509.1 histidinol-phosphate transaminase -
E0E38_RS15570 (3067388) 3067388..3068455 + 1068 WP_000080086.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T288301 WP_000767829.1 NZ_LR213458:c3063385-3063131 [Shigella sonnei]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT288301 WP_001259255.1 NZ_LR213458:c3063633-3063382 [Shigella sonnei]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References