Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 1301282..1301823 Replicon chromosome
Accession NZ_LR213458
Organism Shigella sonnei strain AUSMDU00008333 isolate AUSMDU00008333

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag E0E38_RS06300 Protein ID WP_000615976.1
Coordinates 1301282..1301560 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag E0E38_RS06305 Protein ID WP_000729704.1
Coordinates 1301563..1301823 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E38_RS06285 (1298864) 1298864..1299442 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
E0E38_RS06290 (1299648) 1299648..1300415 + 768 WP_000333380.1 class II glutamine amidotransferase -
E0E38_RS06295 (1300386) 1300386..1301126 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
E0E38_RS06300 (1301282) 1301282..1301560 - 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
E0E38_RS06305 (1301563) 1301563..1301823 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
E0E38_RS06310 (1302009) 1302009..1302782 + 774 WP_127148796.1 C40 family peptidase -
E0E38_RS06320 (1303823) 1303823..1303951 + 129 Protein_1209 ISAs1 family transposase -
E0E38_RS06325 (1304022) 1304022..1304519 + 498 WP_000006258.1 REP-associated tyrosine transposase RayT -
E0E38_RS06330 (1304642) 1304642..1306354 - 1713 Protein_1211 flagellar biosynthesis protein FlhA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 1291132..1304519 13387


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T288293 WP_000615976.1 NZ_LR213458:c1301560-1301282 [Shigella sonnei]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT288293 WP_000729704.1 NZ_LR213458:c1301823-1301563 [Shigella sonnei]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References