Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1569237..1569900 Replicon chromosome
Accession NC_020209
Organism Pseudomonas poae RE*1-1-14

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H045_RS24375 Protein ID WP_015371867.1
Coordinates 1569237..1569602 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID L7HBN6
Locus tag H045_RS07090 Protein ID WP_003235588.1
Coordinates 1569595..1569900 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H045_RS07060 1564451..1565041 + 591 WP_015371863.1 histidine phosphatase family protein -
H045_RS07065 1565051..1565806 + 756 WP_015371864.1 precorrin-6A synthase (deacetylating) -
H045_RS07070 1565818..1566537 + 720 WP_003235579.1 alpha/beta fold hydrolase -
H045_RS07075 1566607..1567158 - 552 WP_015371865.1 hypothetical protein -
H045_RS07080 1567232..1569040 - 1809 WP_015371866.1 monovalent cation:proton antiporter-2 (CPA2) family protein -
H045_RS24375 1569237..1569602 + 366 WP_015371867.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H045_RS07090 1569595..1569900 + 306 WP_003235588.1 XRE family transcriptional regulator Antitoxin
H045_RS07095 1569988..1571544 + 1557 WP_015371868.1 DUF726 domain-containing protein -
H045_RS07100 1571583..1572902 + 1320 WP_015371869.1 Nramp family divalent metal transporter -
H045_RS07105 1572929..1573306 - 378 WP_015371870.1 type II toxin-antitoxin system VapC family toxin -
H045_RS07110 1573303..1573542 - 240 WP_015371871.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
H045_RS07115 1573797..1574729 - 933 WP_003235598.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(26-86)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13894.46 Da        Isoelectric Point: 6.3756

>T28829 WP_015371867.1 NC_020209:1569237-1569602 [Pseudomonas poae RE*1-1-14]
MSWDIEYTDEFGDWWADLDTGEQSSVSASVDLLGLFGPDLRFPHSSDVKGSRHGNLRELRAQHAGRPYRVLYAFDPLRCA
LLLFGGNKAARHRWYEEHVPVADKLYDVHLETLRKEGRNHG

Download         Length: 366 bp

>T28829 NC_020209:1569237-1569602 [Pseudomonas poae RE*1-1-14]
ATGAGCTGGGACATAGAATACACGGACGAATTCGGAGACTGGTGGGCTGATCTGGATACAGGAGAGCAATCCTCGGTATC
TGCCAGCGTTGATCTGCTGGGGCTGTTCGGGCCAGATTTGCGCTTTCCCCACAGCAGCGATGTCAAGGGATCTCGACACG
GTAACCTGCGCGAACTGAGGGCGCAGCACGCTGGTCGCCCATATAGGGTGCTGTATGCATTCGATCCCCTCCGTTGCGCA
TTGCTGTTGTTTGGTGGCAATAAAGCAGCGCGGCATCGATGGTACGAAGAGCACGTCCCCGTGGCTGATAAGTTGTATGA
CGTTCATTTGGAAACACTGCGTAAAGAGGGCCGTAACCATGGCTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11657.48 Da        Isoelectric Point: 9.7192

>AT28829 WP_003235588.1 NC_020209:1569595-1569900 [Pseudomonas poae RE*1-1-14]
MARKFAELQARMSPESRAEAEQIFRQHLREMPLHELRKAQQLSQESMAKALKVNQAAVSKMERRTDMYISTLRNYIRAMG
GELEIIATFPDGQVKIDNFAC

Download         Length: 306 bp

>AT28829 NC_020209:1569595-1569900 [Pseudomonas poae RE*1-1-14]
ATGGCTAGGAAATTCGCTGAACTTCAAGCTCGCATGTCACCCGAATCGCGGGCTGAGGCCGAGCAGATATTCAGGCAGCA
TCTGAGAGAAATGCCGTTGCATGAGCTGCGCAAAGCCCAGCAGTTGAGCCAGGAGAGCATGGCCAAGGCATTGAAGGTCA
ACCAGGCTGCGGTCTCCAAAATGGAGCGTCGCACGGACATGTATATCAGCACCTTGCGTAACTACATACGCGCCATGGGA
GGTGAACTAGAAATCATCGCGACGTTTCCCGACGGGCAGGTGAAGATCGACAACTTCGCTTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB L7HBN6

References