288278

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3602021..3602865 Replicon chromosome
Accession NZ_LR213455
Organism Shigella flexneri strain AUSMDU00008332 isolate AUSMDU00008332

Toxin (Protein)


Gene name itaT Uniprot ID -
Locus tag E0E35_RS18835 Protein ID WP_014532172.1
Coordinates 3602404..3602865 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID A5H0K0
Locus tag E0E35_RS18825 Protein ID WP_005053053.1
Coordinates 3602021..3602332 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E35_RS18800 (3597492) 3597492..3597989 + 498 Protein_3575 COX aromatic rich motif-containing protein -
E0E35_RS18805 (3598011) 3598011..3600002 + 1992 Protein_3576 cytochrome o ubiquinol oxidase subunit I -
E0E35_RS18810 (3599992) 3599992..3600606 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
E0E35_RS18815 (3600606) 3600606..3600935 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
E0E35_RS18820 (3600947) 3600947..3601837 + 891 WP_000971346.1 heme o synthase -
E0E35_RS18825 (3602021) 3602021..3602332 + 312 WP_005053053.1 DUF1778 domain-containing protein Antitoxin
E0E35_RS18835 (3602404) 3602404..3602865 + 462 WP_014532172.1 GNAT family N-acetyltransferase Toxin
E0E35_RS18845 (3603761) 3603761..3605914 + 2154 WP_005060811.1 SEL1-like repeat protein -
E0E35_RS18850 (3605967) 3605967..3607697 + 1731 WP_000645013.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3602913..3603416 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-133)

Antitoxin

Vibrio phage ICP1, Orf50

(15-97)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 16623.52 Da        Isoelectric Point: 9.9538

>T288278 WP_014532172.1 NZ_LR213455:3602404-3602865 [Shigella flexneri]
MIAVTLLSINLYALRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLERQRVSGVLQGSQPSEIGVVRLVMLGGAR
KYQKRGFGQDLLCDFFEHVKKIHPALPIKGVYLDADPAAINFYARLGFVQLSATPNAFGAVPMFLAIQHILAA

Download         Length: 462 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11394.07 Da        Isoelectric Point: 10.3388

>AT288278 WP_005053053.1 NZ_LR213455:3602021-3602332 [Shigella flexneri]
MPGKTAALYDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A5H0K0

References