Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3354418..3355036 Replicon chromosome
Accession NZ_LR213452
Organism Shigella flexneri strain AUSMDU00008355 isolate AUSMDU00008355

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag E0E33_RS17470 Protein ID WP_001291435.1
Coordinates 3354818..3355036 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q0T7C3
Locus tag E0E33_RS17465 Protein ID WP_000344797.1
Coordinates 3354418..3354792 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E33_RS17455 3349507..3350700 + 1194 WP_024260158.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
E0E33_RS17460 3350723..3353872 + 3150 WP_001132485.1 multidrug efflux RND transporter permease subunit -
E0E33_RS17465 3354418..3354792 + 375 WP_000344797.1 Hha toxicity modulator TomB Antitoxin
E0E33_RS17470 3354818..3355036 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
E0E33_RS17475 3355208..3355759 + 552 WP_000102577.1 maltose O-acetyltransferase -
E0E33_RS17480 3355875..3356345 + 471 WP_000136192.1 YlaC family protein -
E0E33_RS17485 3356509..3358059 + 1551 WP_005106783.1 cyclic-guanylate-specific phosphodiesterase PdeB -
E0E33_RS17490 3358101..3358454 - 354 WP_000878140.1 DUF1428 domain-containing protein -
E0E33_RS17500 3358833..3359144 + 312 WP_000409911.1 MGMT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3359174..3360502 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T288253 WP_001291435.1 NZ_LR213452:3354818-3355036 [Shigella flexneri]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14513.38 Da        Isoelectric Point: 4.9091

>AT288253 WP_000344797.1 NZ_LR213452:3354418-3354792 [Shigella flexneri]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQALQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TPD8

References