Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3072443..3073010 Replicon chromosome
Accession NZ_LR213452
Organism Shigella flexneri strain AUSMDU00008355 isolate AUSMDU00008355

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E0E33_RS16025 Protein ID WP_130862220.1
Coordinates 3072443..3072712 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID Q32DW6
Locus tag E0E33_RS16030 Protein ID WP_000147081.1
Coordinates 3072702..3073010 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E33_RS15990 3067550..3067750 - 201 WP_000111769.1 protein ninH -
E0E33_RS15995 3067845..3068102 - 258 WP_001064799.1 hypothetical protein -
E0E33_RS16000 3068099..3069490 - 1392 WP_000211324.1 replicative DNA helicase -
E0E33_RS16005 3069487..3070365 - 879 WP_000988183.1 ATP-binding protein -
E0E33_RS16010 3070376..3071284 - 909 WP_001247840.1 hypothetical protein -
E0E33_RS16015 3071271..3071504 - 234 WP_000618004.1 hypothetical protein -
E0E33_RS16020 3071501..3072517 - 1017 Protein_3048 Rha family transcriptional regulator -
E0E33_RS16025 3072443..3072712 + 270 WP_130862220.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E0E33_RS16030 3072702..3073010 + 309 WP_000147081.1 helix-turn-helix transcriptional regulator Antitoxin
E0E33_RS16035 3073052..3073228 - 177 WP_001252556.1 NinE family protein -
E0E33_RS16040 3073225..3073635 - 411 WP_000814621.1 recombination protein NinB -
E0E33_RS16050 3074898..3075005 - 108 WP_075332776.1 lysozyme -
E0E33_RS16055 3075005..3075133 - 129 Protein_3055 holin -
E0E33_RS16060 3075198..3076327 + 1130 WP_130862222.1 IS3 family transposase -
E0E33_RS16065 3076428..3077309 + 882 WP_024219169.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ipaH4.5 3034717..3118093 83376


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(4-83)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-97)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10324.08 Da        Isoelectric Point: 10.7080

>T288252 WP_130862220.1 NZ_LR213452:3072443-3072712 [Shigella flexneri]
MSMRARYQHLVERMKVYGSNLGEPHTSAFGDGLFELRIKGNDGIARVFYCTLTGKRIIMLHSFVKKAQKTPPAERKKAET
RMKEVKHDW

Download         Length: 270 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11185.94 Da        Isoelectric Point: 8.5840

>AT288252 WP_000147081.1 NZ_LR213452:3072702-3073010 [Shigella flexneri]
MTGKRTLPTMTHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLASGISG
PSFATLKKFARATGKKLQIRFV

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TJC1

References