Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
Location | 243272..243807 | Replicon | plasmid 2 |
Accession | NZ_LR135476 | ||
Organism | Enterococcus faecium isolate E8423 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | R2PQC0 |
Locus tag | EQB52_RS15230 | Protein ID | WP_002314366.1 |
Coordinates | 243272..243544 (-) | Length | 91 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | Q3Y220 |
Locus tag | EQB52_RS15235 | Protein ID | WP_002297422.1 |
Coordinates | 243544..243807 (-) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EQB52_RS15185 | 238378..238827 | - | 450 | WP_010729386.1 | TlpA family protein disulfide reductase | - |
EQB52_RS15725 | 238983..239525 | - | 543 | WP_002298088.1 | hypothetical protein | - |
EQB52_RS15200 | 239800..240443 | + | 644 | Protein_268 | transposase | - |
EQB52_RS15205 | 240519..241199 | + | 681 | WP_002331383.1 | IS6-like element IS1216 family transposase | - |
EQB52_RS15210 | 241258..241446 | - | 189 | Protein_270 | hypothetical protein | - |
EQB52_RS15215 | 241447..242304 | - | 858 | WP_002292680.1 | AAA family ATPase | - |
EQB52_RS15220 | 242589..242876 | - | 288 | WP_002300557.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
EQB52_RS15225 | 242866..243195 | - | 330 | WP_002292678.1 | AbrB family transcriptional regulator | - |
EQB52_RS15230 | 243272..243544 | - | 273 | WP_002314366.1 | Txe/YoeB family addiction module toxin | Toxin |
EQB52_RS15235 | 243544..243807 | - | 264 | WP_002297422.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
EQB52_RS15240 | 244041..244949 | + | 909 | WP_002295743.1 | IS982-like element ISEfm1 family transposase | - |
EQB52_RS15245 | 244952..246127 | - | 1176 | WP_002336205.1 | MFS transporter | - |
EQB52_RS15250 | 246130..248379 | - | 2250 | WP_106017163.1 | alpha-galactosidase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | aac(6')-aph(2'') | - | 1..256660 | 256660 | |
- | inside | IScluster/Tn | - | - | 231709..254408 | 22699 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829F704 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829F006 |