288216

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 35809..36328 Replicon plasmid 4
Accession NZ_LR135446
Organism Enterococcus faecium isolate E7114

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag FSA55_RS15780 Protein ID WP_000588503.1
Coordinates 36071..36328 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag FSA55_RS15775 Protein ID WP_000388479.1
Coordinates 35809..36078 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FSA55_RS15745 31594..32010 - 417 WP_001232859.1 hypothetical protein -
FSA55_RS15750 32013..32297 - 285 WP_000353844.1 hypothetical protein -
FSA55_RS15755 33796..34476 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
FSA55_RS15760 34552..35118 + 567 Protein_40 hypothetical protein -
FSA55_RS15765 35283..35483 + 201 WP_001033544.1 4-hydroxybenzoate octaprenyltransferase -
FSA55_RS15770 35499..35678 + 180 WP_001120991.1 hypothetical protein -
FSA55_RS15775 35809..36078 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FSA55_RS15780 36071..36328 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
FSA55_RS15785 36703..37875 - 1173 WP_000195429.1 IS256-like element IS256 family transposase -
FSA55_RS15790 38298..39122 + 825 WP_001809248.1 hypothetical protein -
FSA55_RS15795 39287..39901 - 615 WP_001261742.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1..44438 44438
- inside IScluster/Tn erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1657..37875 36218


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T288216 WP_000588503.1 NZ_LR135446:36071-36328 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT288216 WP_000388479.1 NZ_LR135446:35809-36078 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References