Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 129607..130142 Replicon plasmid 2
Accession NZ_LR135436
Organism Enterococcus faecium isolate E8691

Toxin (Protein)


Gene name yoeB Uniprot ID R2PQC0
Locus tag EQB50_RS14205 Protein ID WP_002314366.1
Coordinates 129607..129879 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q3Y220
Locus tag EQB50_RS14210 Protein ID WP_002297422.1
Coordinates 129879..130142 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB50_RS14175 125006..125639 - 634 Protein_122 peptidase -
EQB50_RS14180 125899..126447 - 549 WP_002292681.1 hypothetical protein -
EQB50_RS14185 126448..127305 - 858 WP_002292680.1 AAA family ATPase -
EQB50_RS14190 127478..128656 - 1179 WP_002324322.1 IS256-like element ISEfm2 family transposase -
EQB50_RS14195 128924..129211 - 288 WP_002300557.1 type II toxin-antitoxin system RelE/ParE family toxin -
EQB50_RS14200 129201..129530 - 330 WP_002292678.1 AbrB family transcriptional regulator -
EQB50_RS14205 129607..129879 - 273 WP_002314366.1 Txe/YoeB family addiction module toxin Toxin
EQB50_RS14210 129879..130142 - 264 WP_002297422.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EQB50_RS14215 130376..131284 + 909 WP_127824026.1 IS982-like element ISEfm1 family transposase -
EQB50_RS14220 131287..132462 - 1176 WP_002323312.1 MFS transporter -
EQB50_RS14225 132465..134714 - 2250 WP_002323313.1 alpha-galactosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..144068 144068
- inside IScluster/Tn - - 127478..143282 15804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10780.24 Da        Isoelectric Point: 9.9724

>T288209 WP_002314366.1 NZ_LR135436:c129879-129607 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ

Download         Length: 273 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9959.22 Da        Isoelectric Point: 4.5370

>AT288209 WP_002297422.1 NZ_LR135436:c130142-129879 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829F704

Antitoxin

Source ID Structure
AlphaFold DB A0A829F006

References