Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 232413..232948 Replicon plasmid 2
Accession NZ_LR135420
Organism Enterococcus faecium isolate E8440

Toxin (Protein)


Gene name yoeB Uniprot ID R2PQC0
Locus tag FQ475_RS15675 Protein ID WP_002314366.1
Coordinates 232413..232685 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q3Y220
Locus tag FQ475_RS15680 Protein ID WP_002297422.1
Coordinates 232685..232948 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQ475_RS15640 227969..228612 + 644 Protein_229 IS3-like element ISEfa8 family transposase -
FQ475_RS15645 228688..229368 + 681 WP_002331383.1 IS6-like element IS1216 family transposase -
FQ475_RS15650 229402..229779 - 378 WP_010729388.1 hypothetical protein -
FQ475_RS15655 230039..230587 - 549 WP_002292681.1 hypothetical protein -
FQ475_RS15660 230588..231445 - 858 WP_002292680.1 ParA family protein -
FQ475_RS15665 231731..232017 - 287 Protein_234 type II toxin-antitoxin system RelE/ParE family toxin -
FQ475_RS15670 232007..232336 - 330 WP_002292678.1 AbrB family transcriptional regulator -
FQ475_RS15675 232413..232685 - 273 WP_002314366.1 Txe/YoeB family addiction module toxin Toxin
FQ475_RS15680 232685..232948 - 264 WP_002297422.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FQ475_RS15685 233182..234090 + 909 Protein_238 IS982-like element ISEfm1 family transposase -
FQ475_RS15690 234093..235268 - 1176 WP_002336205.1 MFS transporter -
FQ475_RS15695 235271..237520 - 2250 WP_002314387.1 alpha-galactosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid dfrG - 1..245801 245801
- inside IScluster/Tn - - 218989..243549 24560


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10780.24 Da        Isoelectric Point: 9.9724

>T288201 WP_002314366.1 NZ_LR135420:c232685-232413 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ

Download         Length: 273 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9959.22 Da        Isoelectric Point: 4.5370

>AT288201 WP_002297422.1 NZ_LR135420:c232948-232685 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829F704

Antitoxin

Source ID Structure
AlphaFold DB A0A829F006

References