Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 202851..203386 Replicon plasmid 2
Accession NZ_LR135244
Organism Enterococcus faecium isolate E6988

Toxin (Protein)


Gene name yoeB Uniprot ID R2PQC0
Locus tag EQB64_RS15155 Protein ID WP_002314366.1
Coordinates 202851..203123 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q3Y220
Locus tag EQB64_RS15160 Protein ID WP_002297422.1
Coordinates 203123..203386 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB64_RS15125 198250..198883 - 634 Protein_193 peptidase -
EQB64_RS15130 199143..199691 - 549 WP_002292681.1 hypothetical protein -
EQB64_RS15135 199692..200549 - 858 WP_002292680.1 AAA family ATPase -
EQB64_RS15140 200722..201900 - 1179 WP_002324322.1 IS256-like element ISEfm2 family transposase -
EQB64_RS15145 202168..202455 - 288 WP_002300557.1 type II toxin-antitoxin system RelE/ParE family toxin -
EQB64_RS15150 202445..202774 - 330 WP_002292678.1 AbrB family transcriptional regulator -
EQB64_RS15155 202851..203123 - 273 WP_002314366.1 Txe/YoeB family addiction module toxin Toxin
EQB64_RS15160 203123..203386 - 264 WP_002297422.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EQB64_RS15165 203620..204528 + 909 Protein_201 IS982 family transposase -
EQB64_RS15170 204531..205706 - 1176 WP_002336205.1 MFS transporter -
EQB64_RS15175 205709..207958 - 2250 WP_002314387.1 alpha-galactosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(6')-aph(2'') / aph(2'')-Ia - 1..216239 216239
- inside IScluster/Tn - - 200722..213987 13265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10780.24 Da        Isoelectric Point: 9.9724

>T288094 WP_002314366.1 NZ_LR135244:c203123-202851 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ

Download         Length: 273 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9959.22 Da        Isoelectric Point: 4.5370

>AT288094 WP_002297422.1 NZ_LR135244:c203386-203123 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829F704

Antitoxin

Source ID Structure
AlphaFold DB A0A829F006

References