Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 154558..155093 Replicon plasmid 2
Accession NZ_LR135236
Organism Enterococcus faecium isolate E7067

Toxin (Protein)


Gene name yoeB Uniprot ID R2PQC0
Locus tag EQB63_RS15020 Protein ID WP_002314366.1
Coordinates 154558..154830 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q3Y220
Locus tag EQB63_RS15025 Protein ID WP_002297422.1
Coordinates 154830..155093 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB63_RS14985 150114..150757 + 644 Protein_158 transposase -
EQB63_RS14990 150833..151513 + 681 WP_002331383.1 IS6-like element IS1216 family transposase -
EQB63_RS14995 151568..151924 - 357 Protein_160 hypothetical protein -
EQB63_RS15000 152184..152732 - 549 WP_002292681.1 hypothetical protein -
EQB63_RS15005 152733..153590 - 858 WP_002292680.1 AAA family ATPase -
EQB63_RS15010 153876..154162 - 287 Protein_163 type II toxin-antitoxin system RelE/ParE family toxin -
EQB63_RS15015 154152..154481 - 330 WP_002292678.1 AbrB family transcriptional regulator -
EQB63_RS15020 154558..154830 - 273 WP_002314366.1 Txe/YoeB family addiction module toxin Toxin
EQB63_RS15025 154830..155093 - 264 WP_002297422.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EQB63_RS15030 155327..156235 + 909 Protein_167 IS982 family transposase -
EQB63_RS15035 156238..157413 - 1176 WP_002336205.1 MFS transporter -
EQB63_RS15040 157416..159665 - 2250 WP_002314387.1 alpha-galactosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(6')-aph(2'') - 1..167946 167946
- inside IScluster/Tn - - 140677..165694 25017


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10780.24 Da        Isoelectric Point: 9.9724

>T288085 WP_002314366.1 NZ_LR135236:c154830-154558 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ

Download         Length: 273 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9959.22 Da        Isoelectric Point: 4.5370

>AT288085 WP_002297422.1 NZ_LR135236:c155093-154830 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829F704

Antitoxin

Source ID Structure
AlphaFold DB A0A829F006

References