Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3921487..3922180 Replicon chromosome
Accession NC_020163
Organism Escherichia coli APEC O78

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag APECO78_RS19665 Protein ID WP_000415584.1
Coordinates 3921884..3922180 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag APECO78_RS19660 Protein ID WP_000650107.1
Coordinates 3921487..3921882 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APECO78_RS19650 3917351..3919609 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
APECO78_RS19655 3919747..3921354 - 1608 WP_001701096.1 ABC transporter substrate-binding protein -
APECO78_RS19660 3921487..3921882 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
APECO78_RS19665 3921884..3922180 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
APECO78_RS19670 3922385..3922867 - 483 WP_000183494.1 transcriptional regulator -
APECO78_RS19675 3922920..3923312 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
APECO78_RS19680 3923463..3924122 + 660 WP_001221491.1 two-component system response regulator QseB -
APECO78_RS19685 3924119..3925468 + 1350 WP_000673406.1 two-component system sensor histidine kinase QseC -
APECO78_RS19690 3925578..3926159 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
APECO78_RS19695 3926190..3926504 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T28806 WP_000415584.1 NC_020163:c3922180-3921884 [Escherichia coli APEC O78]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T28806 NC_020163:c3922180-3921884 [Escherichia coli APEC O78]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT28806 WP_000650107.1 NC_020163:c3921882-3921487 [Escherichia coli APEC O78]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT28806 NC_020163:c3921882-3921487 [Escherichia coli APEC O78]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References