Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 130901..131436 Replicon plasmid 2
Accession NZ_LR135192
Organism Enterococcus faecium isolate E4438

Toxin (Protein)


Gene name yoeB Uniprot ID R2PQC0
Locus tag EL354_RS14720 Protein ID WP_002314366.1
Coordinates 130901..131173 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q3Y220
Locus tag EL354_RS14725 Protein ID WP_002297422.1
Coordinates 131173..131436 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL354_RS14690 126300..126933 - 634 Protein_123 peptidase -
EL354_RS14695 127193..127741 - 549 WP_002292681.1 hypothetical protein -
EL354_RS14700 127742..128599 - 858 WP_002292680.1 AAA family ATPase -
EL354_RS14705 128772..129950 - 1179 WP_002324322.1 IS256-like element ISEfm2 family transposase -
EL354_RS14710 130218..130505 - 288 WP_002300557.1 type II toxin-antitoxin system RelE/ParE family toxin -
EL354_RS14715 130495..130824 - 330 WP_002292678.1 AbrB family transcriptional regulator -
EL354_RS14720 130901..131173 - 273 WP_002314366.1 Txe/YoeB family addiction module toxin Toxin
EL354_RS14725 131173..131436 - 264 WP_002297422.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EL354_RS14730 131670..132578 + 909 WP_002295743.1 IS982-like element ISEfm1 family transposase -
EL354_RS14735 132581..133756 - 1176 WP_002323312.1 MFS transporter -
EL354_RS14740 133759..136008 - 2250 WP_002323313.1 alpha-galactosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..145361 145361
- inside IScluster/Tn - - 128772..144575 15803


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10780.24 Da        Isoelectric Point: 9.9724

>T288057 WP_002314366.1 NZ_LR135192:c131173-130901 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ

Download         Length: 273 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9959.22 Da        Isoelectric Point: 4.5370

>AT288057 WP_002297422.1 NZ_LR135192:c131436-131173 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829F704

Antitoxin

Source ID Structure
AlphaFold DB A0A829F006

References