Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1540378..1541005 Replicon chromosome
Accession NZ_LR134529
Organism Bartonella vinsonii strain NCTC12905

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EL291_RS06970 Protein ID WP_126603699.1
Coordinates 1540691..1541005 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag EL291_RS06965 Protein ID WP_019220222.1
Coordinates 1540378..1540674 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL291_RS06925 1535867..1536187 + 321 WP_126604052.1 hypothetical protein -
EL291_RS06930 1536191..1536775 + 585 WP_197721505.1 hypothetical protein -
EL291_RS06945 1537569..1538285 + 717 WP_126603695.1 heat-labile enterotoxin subunit alpha -
EL291_RS06950 1538613..1538912 + 300 WP_126603696.1 hypothetical protein -
EL291_RS06955 1539317..1540057 + 741 WP_126603697.1 phage regulatory protein/antirepressor Ant -
EL291_RS06960 1540054..1540332 + 279 WP_126603698.1 hypothetical protein -
EL291_RS06965 1540378..1540674 - 297 WP_019220222.1 HigA family addiction module antidote protein Antitoxin
EL291_RS06970 1540691..1541005 - 315 WP_126603699.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL291_RS06975 1541068..1541616 + 549 WP_126603700.1 hypothetical protein -
EL291_RS06980 1541606..1543552 + 1947 WP_126603701.1 phage terminase large subunit family protein -
EL291_RS06985 1543556..1543804 + 249 WP_126603702.1 hypothetical protein -
EL291_RS06990 1543804..1545348 + 1545 WP_126603703.1 phage portal protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1521516..1575974 54458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(15-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12121.90 Da        Isoelectric Point: 9.0985

>T288016 WP_126603699.1 NZ_LR134529:c1541005-1540691 [Bartonella vinsonii]
MIHKRTNEGDLVIESFADKRCKDLLEGNPPRGFPSTLVRIAQRKLFMLDKAVDLKDLRSPPGNRLEALKGERKGQYSIRI
NDQFRICFEWRSNGAYEVEIVDYH

Download         Length: 315 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11335.02 Da        Isoelectric Point: 5.1546

>AT288016 WP_019220222.1 NZ_LR134529:c1540674-1540378 [Bartonella vinsonii]
MKNYIAIHPGEILREEYLKEYALSAYALAKALNVPRTRIERIVAENSPITPDTALRLAYFFDTTAEFWLNMQAAYDVSIL
QTEKADEFAKINKFECRV

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References