28801

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2840591..2841093 Replicon chromosome
Accession NC_020163
Organism Escherichia coli APEC O78

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag APECO78_RS14405 Protein ID WP_000767829.1
Coordinates 2840591..2840845 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag APECO78_RS14410 Protein ID WP_001259255.1
Coordinates 2840842..2841093 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APECO78_RS14380 2835607..2835834 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
APECO78_RS14385 2835848..2836906 - 1059 WP_000492346.1 transport protein YeeE -
APECO78_RS14390 2837084..2838442 - 1359 WP_015364500.1 putrescine/proton symporter PlaP -
APECO78_RS26760 2838432..2838494 - 63 WP_010723108.1 membrane protein YoeI -
APECO78_RS14395 2838709..2839638 - 930 WP_000803351.1 LysR family transcriptional regulator -
APECO78_RS14400 2839684..2840508 - 825 WP_000754758.1 SDR family oxidoreductase -
APECO78_RS14405 2840591..2840845 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
APECO78_RS14410 2840842..2841093 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
APECO78_RS25290 2841377..2841427 + 51 WP_001364200.1 his operon leader peptide -
APECO78_RS14415 2841573..2842472 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
APECO78_RS14420 2842478..2843782 + 1305 WP_001317939.1 histidinol dehydrogenase -
APECO78_RS14425 2843779..2844849 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
APECO78_RS14430 2844849..2845916 + 1068 WP_000080076.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T28801 WP_000767829.1 NC_020163:c2840845-2840591 [Escherichia coli APEC O78]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T28801 NC_020163:c2840845-2840591 [Escherichia coli APEC O78]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT28801 WP_001259255.1 NC_020163:c2841093-2840842 [Escherichia coli APEC O78]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT28801 NC_020163:c2841093-2840842 [Escherichia coli APEC O78]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References