Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 227162..227675 Replicon chromosome
Accession NZ_LR134520
Organism Streptococcus agalactiae strain NCTC13947

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag EL267_RS01290 Protein ID WP_000481712.1
Coordinates 227421..227675 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag EL267_RS01285 Protein ID WP_000387490.1
Coordinates 227162..227428 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL267_RS01250 223428..224660 + 1233 WP_000338839.1 replication initiation factor domain-containing protein -
EL267_RS01255 224676..225053 + 378 WP_000287184.1 hypothetical protein -
EL267_RS01260 225037..225252 + 216 WP_057486793.1 helix-turn-helix domain-containing protein -
EL267_RS01265 225245..225598 + 354 WP_000571928.1 helix-turn-helix domain-containing protein -
EL267_RS01270 225730..226002 + 273 WP_000072642.1 hypothetical protein -
EL267_RS01275 226054..226536 + 483 WP_000383282.1 antirestriction protein ArdA -
EL267_RS01280 226544..227017 + 474 WP_000560386.1 hypothetical protein -
EL267_RS01285 227162..227428 + 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
EL267_RS01290 227421..227675 + 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
EL267_RS01295 227728..228681 + 954 WP_057486791.1 conjugal transfer protein -
EL267_RS01300 228701..228967 + 267 WP_001055036.1 hypothetical protein -
EL267_RS01305 228971..229381 + 411 WP_000390748.1 conjugal transfer protein -
EL267_RS01310 229402..231903 + 2502 WP_000239405.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 210447..242905 32458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T288002 WP_000481712.1 NZ_LR134520:227421-227675 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT288002 WP_000387490.1 NZ_LR134520:227162-227428 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References