Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 1389433..1390021 Replicon chromosome
Accession NZ_LR134519
Organism Helicobacter pylori strain NCTC12823

Toxin (Protein)


Gene name TfiT Uniprot ID -
Locus tag EL264_RS06740 Protein ID WP_126474679.1
Coordinates 1389433..1389714 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID A0A0B2EMJ7
Locus tag EL264_RS06745 Protein ID WP_042633499.1
Coordinates 1389707..1390021 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL264_RS06705 (NCTC12823_01335) 1384633..1384896 + 264 WP_126474675.1 hypothetical protein -
EL264_RS06710 (NCTC12823_01336) 1384893..1385192 + 300 WP_001974502.1 hypothetical protein -
EL264_RS06715 (NCTC12823_01337) 1385192..1386133 + 942 WP_126474676.1 ATPase, T2SS/T4P/T4SS family -
EL264_RS06720 (NCTC12823_01338) 1386130..1386585 + 456 WP_126474677.1 mobilization protein -
EL264_RS06725 (NCTC12823_01339) 1386582..1386872 + 291 WP_097692878.1 hypothetical protein -
EL264_RS06730 (NCTC12823_01340) 1386873..1387430 + 558 WP_126474678.1 hypothetical protein -
EL264_RS06735 (NCTC12823_01341) 1387431..1389158 + 1728 WP_164757155.1 type IV secretory system conjugative DNA transfer family protein -
EL264_RS06740 (NCTC12823_01342) 1389433..1389714 - 282 WP_126474679.1 YafQ family addiction module toxin Toxin
EL264_RS06745 (NCTC12823_01343) 1389707..1390021 - 315 WP_042633499.1 hypothetical protein Antitoxin
EL264_RS06750 1390305..1392217 + 1913 Protein_1261 relaxase -
EL264_RS06755 (NCTC12823_01346) 1392242..1393432 - 1191 WP_126474680.1 hypothetical protein -
EL264_RS06760 (NCTC12823_01347) 1393476..1393760 - 285 WP_000394655.1 hypothetical protein -
EL264_RS06765 (NCTC12823_01348) 1393842..1394498 - 657 WP_126474681.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10958.98 Da        Isoelectric Point: 9.8257

>T288000 WP_126474679.1 NZ_LR134519:c1389714-1389433 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRIKESDIISIVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12106.56 Da        Isoelectric Point: 5.2066

>AT288000 WP_042633499.1 NZ_LR134519:c1390021-1389707 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNSIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTPSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0B2EMJ7

References