Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/VapI(antitoxin)
Location 2108850..2110289 Replicon chromosome
Accession NZ_LR134514
Organism Pasteurella multocida subsp. septica strain NCTC11619

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EL252_RS09875 Protein ID WP_046338478.1
Coordinates 2109948..2110289 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL252_RS09870 Protein ID WP_126417804.1
Coordinates 2108850..2109935 (-) Length 362 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL252_RS09830 2104173..2104712 - 540 WP_126417796.1 HNH endonuclease -
EL252_RS09835 2104716..2105327 - 612 WP_126417797.1 YqaJ viral recombinase family protein -
EL252_RS09840 2105324..2106106 - 783 WP_126417798.1 phage recombination protein Bet -
EL252_RS09845 2106117..2107070 - 954 WP_126417799.1 hypothetical protein -
EL252_RS11010 2107073..2107234 - 162 WP_014390707.1 hypothetical protein -
EL252_RS09850 2107248..2107475 - 228 WP_126417800.1 hypothetical protein -
EL252_RS09855 2107462..2107752 - 291 WP_126417801.1 hypothetical protein -
EL252_RS09860 2107856..2108152 - 297 WP_126417802.1 hypothetical protein -
EL252_RS09865 2108166..2108393 - 228 WP_126417803.1 hypothetical protein -
EL252_RS09870 2108850..2109935 - 1086 WP_126417804.1 HigA family addiction module antidote protein Antitoxin
EL252_RS09875 2109948..2110289 - 342 WP_046338478.1 killer suppression protein Toxin
EL252_RS09880 2110430..2111116 - 687 WP_126417805.1 helix-turn-helix transcriptional regulator -
EL252_RS09885 2111244..2111453 + 210 WP_005720263.1 helix-turn-helix transcriptional regulator -
EL252_RS09890 2111502..2111954 + 453 WP_126417806.1 hypothetical protein -
EL252_RS09895 2112012..2112695 + 684 WP_078737816.1 phage antirepressor KilAC domain-containing protein -
EL252_RS09900 2112692..2113483 + 792 WP_064964928.1 HNH endonuclease -
EL252_RS09905 2113473..2113679 + 207 Protein_1888 helix-turn-helix domain-containing protein -
EL252_RS09910 2113887..2114311 + 425 Protein_1889 hypothetical protein -
EL252_RS09915 2114311..2115000 + 690 WP_126417884.1 replication protein P -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2090720..2146507 55787


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(15-72)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12888.01 Da        Isoelectric Point: 9.9023

>T287986 WP_046338478.1 NZ_LR134514:c2110289-2109948 [Pasteurella multocida subsp. septica]
MDIIFKSRKLEKELNSEIYILKRYGTVCGKKIKLAMTALRAAPSLQTFFPPYSKPYRCHELLGDRKGQISIDAQHPYRVL
FEANHNPLPTLDAGGLDWSKVTSIRILSITDTH

Download         Length: 342 bp

Antitoxin


Download         Length: 362 a.a.        Molecular weight: 41233.12 Da        Isoelectric Point: 7.5938

>AT287986 WP_126417804.1 NZ_LR134514:c2109935-2108850 [Pasteurella multocida subsp. septica]
MSENQYYPDYAVLPGEVLEFELDGLEISQKELSNKTGISTKHISNIINGKSPITPETAIALERVLGKPARYWLNLETLYQ
EALARIADKKELERHAEWVKQFPNYILQKLGFTQKHTDISSKVDTLLRFFGVASPADYETVWGQIGVQYRQDKRTTICQH
SSSAWLRAGEIKASEIICQPYSESGFKQALEKIKALTKETEPSHFIPELINICASVGVAVVFVPCFPNTGISGATRWLSS
DKAVIQLSLRYKTNDHLWFTFFHEAGHILLHGKKTLHLEFNSKTVLADEETEANDFAQKYLIPRPIWRNLIQKVAVTEQH
IRAAAEEIGIAEGIIVGQLQHYKKLRYDQLNHLKVRYTWQH

Download         Length: 1086 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References