Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1813852..1814640 Replicon chromosome
Accession NZ_LR134514
Organism Pasteurella multocida subsp. septica strain NCTC11619

Toxin (Protein)


Gene name higB Uniprot ID A0A2J9QLH7
Locus tag EL252_RS08345 Protein ID WP_005725755.1
Coordinates 1813852..1814178 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL252_RS08350 Protein ID WP_005757699.1
Coordinates 1814314..1814640 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL252_RS08320 1809170..1809856 + 687 WP_104227953.1 hypothetical protein -
EL252_RS08325 1809910..1811439 - 1530 WP_108511680.1 YifB family Mg chelatase-like AAA ATPase -
EL252_RS08330 1811547..1812164 - 618 WP_005724253.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
EL252_RS08335 1812275..1813144 + 870 WP_005724254.1 VirK/YbjX family protein -
EL252_RS08340 1813218..1813694 - 477 WP_042742721.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
EL252_RS08345 1813852..1814178 + 327 WP_005725755.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL252_RS08350 1814314..1814640 + 327 WP_005757699.1 HigA family addiction module antidote protein Antitoxin
EL252_RS08355 1814695..1816215 - 1521 WP_126417733.1 DUF560 domain-containing protein -
EL252_RS08360 1816274..1816864 - 591 WP_108511676.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
EL252_RS08365 1817136..1818167 - 1032 WP_104884166.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-102)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12892.73 Da        Isoelectric Point: 9.6705

>T287985 WP_005725755.1 NZ_LR134514:1813852-1814178 [Pasteurella multocida subsp. septica]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLSDLRSPPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNFPKITELRLDKHQYRL

Download         Length: 327 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12377.41 Da        Isoelectric Point: 7.2034

>AT287985 WP_005757699.1 NZ_LR134514:1814314-1814640 [Pasteurella multocida subsp. septica]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKISSIDQHNLLEKIA

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9QLH7

Antitoxin

Source ID Structure

References