Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1303568..1304207 Replicon chromosome
Accession NZ_LR134490
Organism Haemophilus influenzae strain NCTC11873

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EL230_RS06450 Protein ID WP_118806538.1
Coordinates 1303568..1303873 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL230_RS06455 Protein ID WP_005650217.1
Coordinates 1303884..1304207 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL230_RS06430 1298999..1301038 - 2040 WP_075985258.1 excinuclease ABC subunit B -
EL230_RS06440 1301652..1302620 - 969 WP_118806537.1 zinc transporter permease subunit ZevB -
EL230_RS06445 1302623..1303243 - 621 WP_110432017.1 zinc transporter binding subunit ZevA -
EL230_RS06450 1303568..1303873 + 306 WP_118806538.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL230_RS06455 1303884..1304207 + 324 WP_005650217.1 HigA family addiction module antidote protein Antitoxin
EL230_RS06460 1304370..1306040 + 1671 WP_005650218.1 energy-dependent translational throttle protein EttA -
EL230_RS06465 1306102..1306443 + 342 WP_005666735.1 SirB2 family protein -
EL230_RS06470 1306448..1308418 + 1971 WP_005666737.1 tRNA(Met) cytidine acetyltransferase TmcA -
EL230_RS09815 1308415..1308588 + 174 WP_005637028.1 DUF5363 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-97)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-82)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12271.91 Da        Isoelectric Point: 9.0853

>T287952 WP_118806538.1 NZ_LR134490:1303568-1303873 [Haemophilus influenzae]
MFNLKREHFRDDYLYRFYQYGDAHSKIPSNLYKVLARKLDMISASENINDLRSPPANHLELLEPKENKIYSIRVNKQYRL
IFKYENNEVNNLYLDPHSYNL

Download         Length: 306 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12347.17 Da        Isoelectric Point: 6.8804

>AT287952 WP_005650217.1 NZ_LR134490:1303884-1304207 [Haemophilus influenzae]
MMTRKPTSVGEILQEEFLEPLSLKISDLAQILDVHRNTASNIVNNSSRITLEMAVKLAKVFDTTPEFWLNLQTRIDLWDL
EHNKRFQQSLANVKPALHRHDTSTFAM

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References